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4.1 Nitrates. Consistent with its known effects on the nitric oxide/cGMP pathway [see Clinical Pharmacology (12.1, 12.2)], VIAGRA was shown to potentiate the hypotensive effects of nitrates, and its administration to patients who are using nitric oxide donors such as organic nitrates or organic nitrites in any form either regularly and/or intermittently is therefore contraindicated. como funciona o viagra masculino O Viagra ajuda a resolver a vida de homens com disfun o er til leve e moderada. Os casos severos n o respondem bem, mesmo com doses mais elevadas. Quanto tempo dura? O Viagra pode levar de O Viagra ajuda a resolver a vida de homens com disfun o er til leve e moderada. Os casos severos n o respondem bem, mesmo com doses mais elevadas. Quanto tempo dura? O Viagra pode levar de 30 minutos a 2 horas para fazer o efeito desejado, com dura o de cerca de 4 horas.